Allosteric control of metal-responsive transcriptional regulators in bacteria.

ABSTRACT: Many transition metals are essential trace nutrients for living organisms, but they are also cytotoxic in high concentrations. Bacteria maintain the delicate balance between metal starvation and toxicity through a complex network of metal homeostasis pathways. These systems are coordinated by the activities of metal-responsive transcription factors-also known as metal-sensor proteins or metalloregulators-that are tuned to sense the bioavailability of specific metals in the cell in order to regulate the expression of genes encoding proteins that contribute to metal homeostasis. Metal binding to a metalloregulator allosterically influences its ability to bind specific DNA sequences through a variety of intricate mechanisms that lie on a continuum between large conformational changes and subt

SUBMITTER: Baksh KA 

PROVIDER: S-EPMC7008368 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature