APOL1 Nephropathy Risk Alleles and Mortality in African American Adults: A Cohort Study.

ABSTRACT:

Rationale & objective

APOL1 nephropathy risk alleles are associated with the development of chronic kidney disease (CKD) in African Americans. Although CKD is an established risk factor for mortality, associations of APOL1 risk alleles with mortality are uncertain.

Study design

Prospective cohort.

Settings & participants

10,380 African American and 17,485 white American participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study.

Exposures

APOL1 nephropathy risk alleles.

Outcomes

All-cause and cause-specific mortality.

Analytical approach

Cox proportional hazards models were used to examine the association of APOL1 high-risk genotypes (2 risk alleles) versus APOL1 low-risk genotypes (0/1 risk allele) with all-cause

SUBMITTER: Gutierrez OM 

PROVIDER: S-EPMC7008402 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature