PET-CT reveals increased intestinal glucose uptake after gastric surgery.

ABSTRACT:

Background

Mechanisms of metabolic improvement after bariatric surgery remain incompletely understood. Intestinal glucose uptake is increased after gastric bypass in rodents, potentially contributing to reduced blood glucose and type 2 diabetes remission.

Objective

We assessed whether intestinal glucose uptake is increased in humans after gastric surgery.

Setting

University Hospital, United States.

Methods

In a retrospective, case-control cohort study, positron emission tomography-computerized tomography scans performed for clinical indications were analyzed to quantify intestinal glucose uptake in patients with or without history of gastric surgery. We identified 19 cases, defined as patients over age 18 with prior gastric surgery (Roux-en-Y gastric bypass [n 

SUBMITTER: Franquet E 

PROVIDER: S-EPMC7008494 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature