Cognitive function in metformin exposed children, born to mothers with PCOS - follow-up of an RCT.

ABSTRACT:

Background

Metformin is widely used in pregnancy to treat gestational diabetes mellitus and polycystic ovary syndrome (PCOS). Association between PCOS and developmental delay in offspring, and larger head circumference of metformin-exposed newborns has been reported. The objective of this study was to explore whether metformin exposure in utero had any effect on offspring cognitive function.

Method

The current study is a follow-up of two randomized, placebo-controlled studies which were conducted at 11 public hospitals in Norway In the baseline studies (conducted in 2000-2003, and 2005-2009), participants were randomized to metformin 1700 and 2000 mg/d or placebo from first trimester to delivery. There was no intervention in the current study. We invited parents of 292 child

SUBMITTER: Greger HK 

PROVIDER: S-EPMC7008569 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature