Countering opioid-induced respiratory depression by non-opioids that are respiratory stimulants.

ABSTRACT: Strong opioid analgesics are the mainstay of therapy for the relief of moderate to severe acute nociceptive pain that may occur post-operatively or following major trauma, as well as for the management of chronic cancer-related pain. Opioid-related adverse effects include nausea and vomiting, sedation, respiratory depression, constipation, tolerance, and addiction/abuse liability. Of these, respiratory depression is of the most concern to clinicians owing to the potential for fatal consequences. In the broader community, opioid overdose due to either prescription or illicit opioids or co-administration with central nervous system depressants may evoke respiratory depression. To address this problem, there is ongoing interest in the identification of non-opioid respiratory stimulants to rev

SUBMITTER: Imam MZ 

PROVIDER: S-EPMC7008602 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature