Galectin-3 and risk of ischaemic stroke: Reasons for Geographic and Racial Differences in Stroke cohort.

ABSTRACT:

Background and purpose

Galectin-3 is a biomarker of atherosclerotic and cardiovascular disease, and may be a useful marker for ischaemic stroke risk.

Methods

The Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort enrolled and examined 30 239 US participants between 2003 and 2007 (41% black, 59% white and 55% in the southeastern stroke belt). Baseline galectin-3 was measured in 526 subjects with incident ischaemic stroke over 5.4 years and in a cohort random sample (CRS) of 947 participants. Cox proportional hazards models were used to calculate hazard ratios (HRs) of ischaemic stroke by quartiles of galectin-3.

Results

In the CRS, galectin-3 was significantly higher with older age, black race, female sex, body mass index, hypertension, diabetes m

SUBMITTER: Arora P 

PROVIDER: S-EPMC7008611 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature