Assessing rodent hippocampal involvement in the novel object recognition task. A review.

ABSTRACT: The novel object recognition (NOR) task has emerged as a popular method for testing the neurobiology of nonspatial memory in rodents. This task exploits the natural tendency of rodents to explore novel items and depending on the amount of time that rodents spend exploring the presented objects, inferences about memory can be established. Despite its wide use, the underlying neural circuitry and mechanisms supporting NOR have not been clearly defined. In particular, considerable debate has focused on whether the hippocampus plays a significant role in the object memory that is encoded, consolidated and then retrieved during discrete stages of the NOR task. Here we analyzed the results of all published reports in which the role of the rodent hippocampus in object memory was inferred from per

SUBMITTER: Cohen SJ 

PROVIDER: S-EPMC7008635 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature