Acute human exposure assessment to tetrahydrocannabinol (Δ⁹-THC).

ABSTRACT: Delta-9-tetrahydrocannabinol (Δ⁹-THC) is a naturally occurring psychoactive compound derived from the hemp plant Cannabis sativa. In 2015, EFSA established an acute reference dose (ARfD) of 1 μg/kg body weight (bw) for Δ⁹-THC and assessed acute dietary exposure from milk and dairy products. This resulted at the most 3% and 13% of the ARfD for adults and toddlers, respectively. Following the European Commission Recommendation 2016/2115 on the monitoring of the presence of Δ⁹-THC in food and the issuing of a new mandate, EFSA assessed the acute human exposure to Δ⁹-THC. 'Standard' food categories were used as proxies for consumption of hemp and hemp-based products. Twelve independent scenarios based on single food categories were considered

SUBMITTER: European Food Safety Authority (EFSA) 

PROVIDER: S-EPMC7008849 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature