Safety evaluation of the food enzyme triacylglycerol lipase from Trichoderma reesei (strain RF10625).

ABSTRACT: The food enzyme triacylglycerol acylhydrolase (EC 3.1.1.3) is produced with a genetically modified Trichoderma reesei strain RF10625 by AB Enzymes. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and recombinant DNA. The food enzyme is intended to be used in baking processes and cereal-based processes. Based on the maximum use levels, dietary exposure to the food enzyme Total Organic Solids (TOS) was estimated to be up to 0.119 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no-observed-adverse-effect-level of 1,000 mg TOS/kg

SUBMITTER: EFSA Panel on Food Contact Materials, Triacylglycerol lipases and Processing Aids (EFSA CEP Panel) 

PROVIDER: S-EPMC7008919 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature