Ets1 Controls the Development of B Cell Autoimmune Responses in a Cell-Intrinsic Manner.

ABSTRACT: Ets1 is emerging as a key transcription factor that is required to prevent autoimmunity in mice and humans. Ets1 is expressed in both B and T cells, and mice lacking Ets1 are characterized by excess B and T cell activation, leading to enhanced formation of Ab-secreting cells and high titers of autoantibodies. In humans, genome-wide association studies have detected associations of single nucleotide polymorphisms in the human ETS1 gene with autoimmune diseases, including lupus. An increased fraction of CD4⁺ T cells from Ets1^-/- mice have an activated effector-memory phenotype, and there are aberrations in differentiation that contribute to the autoimmune phenotype. In vitro studies of B cells suggest that Ets1 may have B cell-intrinsic effects as well. To confir

SUBMITTER: Sunshine A 

PROVIDER: S-EPMC7008956 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature