Alcohol consumption and serum metabolite concentrations in young women.

ABSTRACT:

Purpose

Alcohol consumption is an established breast cancer risk factor, though further research is needed to advance our understanding of the mechanism underlying the association. We used global metabolomics profiling to identify serum metabolites and metabolic pathways that could potentially mediate the alcohol-breast cancer association.

Methods

A cross-sectional analysis of reported alcohol consumption and serum metabolite concentrations was conducted among 211 healthy women 25-29 years old who participated in the Dietary Intervention Study in Children 2006 Follow-Up Study (DISC06). Alcohol-metabolite associations were evaluated using multivariable linear mixed-effects regression.

Results

Alcohol was significantly (FDR p < 0.05) associated with several serum metabo

SUBMITTER: Dorgan JF 

PROVIDER: S-EPMC7008965 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature