Adenosine, Via A_2B Receptors, Inhibits Human (P-SMC) Progenitor Smooth Muscle Cell Growth.

ABSTRACT: c-Kit+ progenitor smooth muscle cells (P-SMCs) can develop into SMCs that contribute to injury-induced neointimal thickening. Here, we investigated whether adenosine reduces P-SMC migration and proliferation and whether this contributes to adenosine's inhibitory actions on neointima formation. In human P-SMCs, 2-chloroadenosine (stable adenosine analogue) and BAY60-6583 (A_2B agonist) inhibited P-SMC proliferation and migration. Likewise, increasing endogenous adenosine by blocking adenosine metabolism with erythro-9-(2-hydroxy-3-nonyl) adenine (inhibits adenosine deaminase) and 5-iodotubercidin (inhibits adenosine kinase) attenuated P-SMC proliferation and migration. Neither N⁶-cyclopentyladenosine (A₁ agonist), CGS21680 (A_2A agonist), nor N

SUBMITTER: Dubey RK 

PROVIDER: S-EPMC7009319 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature