Dataset Information

Evaluation of the impact of glyphosate and its residues in feed on animal health.

ABSTRACT: EFSA was requested by the European Commission to consider the impact of glyphosate residues in feed on animal health in accordance with Article 31 of Regulation (EC) No 178/2002. The current report presents the assessment of the available information on glyphosate residues in feed, including feed imported from outside the European Union (i.e. third countries) and the conclusions on the possible impact of those residues on animal health. The conclusions of this scientific report were reached on the basis of the initial evaluation carried out by the competent authority of the rapporteur Member State, Germany, using data made available by industry, on the existing EFSA Conclusion on glyphosate as well as on the basis of a literature review conducted by EFSA. The current report is delivered at the same time as the EFSA Reasoned Opinion on the review of existing maximum residue levels for glyphosate according to Article 12 of Regulation (EC) No 396/2005. With regard to the assessment of the impact of glyphosate and its residues on animal health, considering the available data, glyphosate is not expected to have a major impact, if any, on animal health.

SUBMITTER: European Food Safety Authority (EFSA)

PROVIDER: S-EPMC7009421 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Evaluation of the impact of glyphosate and its residues in feed on animal health.

EFSA journal. European Food Safety Authority 20180517 5

EFSA was requested by the European Commission to consider the impact of glyphosate residues in feed on animal health in accordance with Article 31 of Regulation (EC) No 178/2002. The current report presents the assessment of the available information on glyphosate residues in feed, including feed imported from outside the European Union (i.e. third countries) and the conclusions on the possible impact of those residues on animal health. The conclusions of this scientific report were reached on t ...[more]

PMID: 32625919

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Project description:Glyphosate (GLY) is worldwide one of the most used active substances in non-selective herbicides. Although livestock might be orally exposed via GLY-contaminated feedstuffs, not much is known about possible hepatotoxic effects of GLY. As hepatic xenobiotic and nutrient metabolism are interlinked, toxic effects of GLY residues might be influenced by hepatic nutrient supply. Therefore, a feeding trial with lactating dairy cows was conducted to investigate effects of GLY-contaminated feedstuffs and different concentrate feed proportions (CFP) in the diets as tool for varying nutrient supply to the liver. For this, 61 German Holstein cows (207 ± 49 days in milk; mean ± standard deviation) were either fed a GLY-contaminated total mixed ration (TMR, GLY groups, mean GLY intake 122.7 μg/kg body weight/day) or control TMR (CON groups, mean GLY intake 1.2 μg/kg body weight/day) for 16 weeks. Additionally, both groups were further split into subgroups fed a lower (LC, 30% on dry matter basis) or higher (HC, 60% on dry matter basis) CFP resulting in groups CONHC (n = 16), CONLC (n = 16), GLYHC (n = 15), GLYLC (n = 14). Blood parameters aspartate aminotransferase, γ-glutamyltransferase, glutamate dehydrogenase, cholesterol, triglyceride, total protein, calcium, phosphorus, acetic acid and urea and histopathological evaluation were not influenced by GLY, whereas all mentioned parameters were at least affected by time, CFP or an interactive manner between time and CFP. Total bilirubin blood concentration was significantly influenced by an interaction between GLY and CFP with temporarily elevated concentrations in GLYHC, whereas the biological relevance remained unclear. Gene expression analysis indicated 167 CFP-responsive genes, while seven genes showed altered expression in GLY groups compared to CON groups. Since expression changes of GLY-responsive genes were low and liver-related blood parameters changed either not at all or only slightly, the tested GLY formulation was considered to have no toxic effects on the liver of dairy cows.

Project description:Glyphosate (GLY) is one of the most used active substances in broad-band herbicides worldwide. Although farm animals might be orally exposed to this herbicide via GLY contaminated feedstuffs, not much is known about possible hepatotoxic effects of GLY. As hepatic xenobiotic and nutrient metabolism are closely interlinked, the toxic effects of GLY residues might be influenced by nutrient supply to the liver. Therefore, a feeding trial with lactating dairy cows was conducted to investigate effects of GLY contaminated feedstuffs and different concentrate feed proportions (CFP) in the diets as a tool for varying nutrient supply to the liver. Therefore, 61 German Holstein cows (207 ± 49 days in milk; mean ± standard deviation) were either fed a GLY contaminated total mixed ration (TMR, GLY, average mean GLY intake 122.7 µg/kg bodyweight/day) or control TMR (CON, average mean GLY intake 1.2 µg/kg bodyweight/day) for 16 weeks. Additionally, both groups were further split into subgroups fed a lower (LC, 30% on dry matter basis) or a higher (HC, 60% on dry matter basis) CFP. Blood parameters aspartate aminotransferase, γ-glutamyltransferase, glutamate dehydrogenase, cholesterol, triglyceride, total protein, calcium, phosphorus, acetic acid and urea as well as histopathological evaluation were not influenced by GLY, whereas all mentioned parameters were at least affected by time, CFP or by an interactive manner between time and CFP. Total bilirubin blood concentration was significantly influenced by an interaction between GLY and CFP with temporarily elevated concentrations in GLYHC, whereas the reasons and biological relevance remain unclear. Gene expression analysis indicated 167 CFP-responsive genes, while seven genes showed altered expression in GLY groups compared to CON groups. Since expression changes of GLY-responsive genes were low and liver-related blood parameters changed either not at all or only slightly, the tested GLY formulation was considered to have no toxic effects on the liver of dairy cows.

Dataset Information

Evaluation of the impact of glyphosate and its residues in feed on animal health.

Publications

Evaluation of the impact of glyphosate and its residues in feed on animal health.

Similar Datasets

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