Subthalamic nucleus activity dynamics and limb movement prediction in Parkinson's disease.

ABSTRACT: Whilst exaggerated bursts of beta frequency band oscillatory synchronization in the subthalamic nucleus have been associated with motor impairment in Parkinson's disease, a plausible mechanism linking the two phenomena has been lacking. Here we test the hypothesis that increased synchronization denoted by beta bursting might compromise information coding capacity in basal ganglia networks. To this end we recorded local field potential activity in the subthalamic nucleus of 18 patients with Parkinson's disease as they executed cued upper and lower limb movements. We used the accuracy of local field potential-based classification of the limb to be moved on each trial as an index of the information held by the system with respect to intended action. Machine learning using the naïve Bayes cond

SUBMITTER: Khawaldeh S 

PROVIDER: S-EPMC7009471 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature