Brain structural covariance networks in obsessive-compulsive disorder: a graph analysis from the ENIGMA Consortium.

ABSTRACT: Brain structural covariance networks reflect covariation in morphology of different brain areas and are thought to reflect common trajectories in brain development and maturation. Large-scale investigation of structural covariance networks in obsessive-compulsive disorder (OCD) may provide clues to the pathophysiology of this neurodevelopmental disorder. Using T1-weighted MRI scans acquired from 1616 individuals with OCD and 1463 healthy controls across 37 datasets participating in the ENIGMA-OCD Working Group, we calculated intra-individual brain structural covariance networks (using the bilaterally-averaged values of 33 cortical surface areas, 33 cortical thickness values, and six subcortical volumes), in which edge weights were proportional to the similarity between two brain morphologi

SUBMITTER: Yun JY 

PROVIDER: S-EPMC7009583 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature