The influence of nicotine metabolic rate on working memory over 6 hours of abstinence from nicotine.

ABSTRACT:

Background

A faster rate of nicotine metabolism has been associated with smoking more cigarettes, greater nicotine withdrawal symptoms, and lower smoking quit rates. However, the association between nicotine metabolic rate (NMR) and cognitive functioning during withdrawal has not been determined.

Methods

We compared cognitive function in 121 fast or slow nicotine metabolizers after smoking, and at 3 and 6 h of nicotine abstinence. Cognitive functioning was assessed using N-back working memory tests with outcomes of accuracy and processing speed. Participants smoked two cigarettes and then abstained from smoking for 6 h. N-back tests were administered after smoking (0 h) and at 3 and 6 h of nicotine abstinence.

Results

An effect of processing speed was found over time

SUBMITTER: Nardone N 

PROVIDER: S-EPMC7009742 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature