The number of k-mer matches between two DNA sequences as a function of k and applications to estimate phylogenetic distances.

ABSTRACT: We study the number Nk of length-k word matches between pairs of evolutionarily related DNA sequences, as a function of k. We show that the Jukes-Cantor distance between two genome sequences-i.e. the number of substitutions per site that occurred since they evolved from their last common ancestor-can be estimated from the slope of a function F that depends on Nk and that is affine-linear within a certain range of k. Integers kmin and kmax can be calculated depending on the length of the input sequences, such that the slope of F in the relevant range can be estimated from the values F(kmin) and F(kmax). This approach can be generalized to so-called Spaced-word Matches (SpaM), where mismatches are allowed at positions specified by a user-defined binary pattern. Based on these theoretical res

SUBMITTER: Rohling S 

PROVIDER: S-EPMC7010260 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature