Risky behaviors and Parkinson disease: A mendelian randomization study.

ABSTRACT:

Objective

To examine causal associations between risky behavior phenotypes and Parkinson disease using a mendelian randomization approach.

Methods

We used 2-sample mendelian randomization to generate unconfounded estimates using summary statistics from 2 independent, large meta-analyses of genome-wide association studies on risk-taking behaviors (n = 370,771-939,908) and Parkinson disease (cases n = 9,581, controls n = 33,245). We used the inverse variance weighted method as the main method for judging causality.

Results

Our results support a strong protective association between the tendency to smoke and Parkinson disease (odds ratio [OR] 0.714 per log odds of ever smoking, 95% confidence interval [CI] 0.568-0.897, p = 0.0041, Cochran Q test p = 0.238;

SUBMITTER: Grover S 

PROVIDER: S-EPMC7010323 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature