Altered corticolimbic connectivity reveals sex-specific adolescent outcomes in a rat model of early life adversity.

ABSTRACT: Exposure to early-life adversity (ELA) increases the risk for psychopathologies associated with amygdala-prefrontal cortex (PFC) circuits. While sex differences in vulnerability have been identified with a clear need for individualized intervention strategies, the neurobiological substrates of ELA-attributable differences remain unknown due to a paucity of translational investigations taking both development and sex into account. Male and female rats exposed to maternal separation ELA were analyzed with anterograde tracing from basolateral amygdala (BLA) to PFC to identify sex-specific innervation trajectories through juvenility (PD28) and adolescence (PD38;PD48). Resting-state functional connectivity (rsFC) was assessed longitudinally (PD28;PD48) in a separate cohort. All measures were re

SUBMITTER: Honeycutt JA 

PROVIDER: S-EPMC7010412 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature