Ultra-High-Resolution Imaging of Amygdala Subnuclei Structural Connectivity in Major Depressive Disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) is an increasingly common and disabling illness. As the amygdala has been reported to have pathological involvement in mood disorders, we aimed to investigate for the first time potential changes to structural connectivity of individual amygdala subnuclei in MDD using ultra-high-field 7T diffusion magnetic resonance imaging.

Methods

Twenty-four patients with MDD (11 women) and 24 age-matched healthy control participants (7 women) underwent diffusion-weighted imaging with a 1.05-mm isotropic resolution at 7T. Amygdala nuclei regions of interest were obtained through automated segmentation of 0.69-mm resolution T1-weighted images and 0.35-mm resolution T2-weighted images. Probabilistic tractography was performed on all subjects, with

SUBMITTER: Brown SSG 

PROVIDER: S-EPMC7010542 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature