Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank.

ABSTRACT:

Background

Clinical and epidemiologic studies have shown that obesity is associated with asthma and that these associations differ by asthma subtype. Little is known about the shared genetic components between obesity and asthma.

Objective

We sought to identify shared genetic associations between obesity-related traits and asthma subtypes in adults.

Methods

A cross-trait genome-wide association study (GWAS) was performed using 457,822 subjects of European ancestry from the UK Biobank. Experimental evidence to support the role of genes significantly associated with both obesity-related traits and asthma through a GWAS was sought by using results from obese versus lean mouse RNA sequencing and RT-PCR experiments.

Results

We found a substantial positive genetic co

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC7010560 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature