Regulation of Craving and Negative Emotion in Alcohol Use Disorder.

ABSTRACT:

Background

Alcohol use disorder (AUD) is a chronic, relapsing condition with poor treatment outcomes. Both alcohol craving and negative affect increase alcohol drinking, and-in healthy adults-can be attenuated using cognitive strategies, which rely on the prefrontal cortex (PFC). However, AUD is associated with cognitive impairments and PFC disruptions. Thus, we tested whether individuals with AUD can successfully recruit the PFC to effectively regulate craving and negative emotions, whether neural mechanisms are shared between the two types of regulation, and whether individual differences influence regulation success.

Methods

During functional magnetic resonance imaging, participants with AUD completed the regulation of craving task (n = 17) that compares a cue-induced cra

SUBMITTER: Suzuki S 

PROVIDER: S-EPMC7010564 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature