Developmental Population Pharmacokinetics and Dosing Optimization of Cefepime in Neonates and Young Infants.

ABSTRACT:

Objective

Cefepime is used to treat severe infections in neonates. Pharmacokinetic data have only been evaluated among preterm neonates and population pharmacokinetic model lacked external validation. Hence, our aim is to obtain the population pharmacokinetic parameters of cefepime with large sampling and optimize the cefepime dosage regimen for neonatal infection based on developmental pharmacokinetics-pharmacodynamics.

Methods

Blood samples from neonates and young infants treated with cefepime were collected using the opportunistic sampling design. The concentration of cefepime was determined using high performance liquid chromatography with ultraviolet detection. The population pharmacokinetic model was established using NONMEM software.

Results

One hundred blood s

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC7010644 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature