Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer.

ABSTRACT: Innate lymphoid cells (ILCs) are largely tissue resident and respond rapidly toward the environmental signals from surrounding tissues and other immune cells. The pleiotropic function of ILCs in diverse contexts underpins its importance in the innate arm of immune system in human health and disease. ILCs derive from common lymphoid progenitors but lack adaptive antigen receptors and functionally act as the innate counterpart to T-cell subsets. The classification of different subtypes is based on their distinct transcription factor requirement for development as well as signature cytokines that they produce. The discovery and subsequent characterization of ILCs over the past decade have mainly focused on the regulation of inflammation, tissue remodeling, and homeostasis, whereas the underst

SUBMITTER: An Z 

PROVIDER: S-EPMC7010811 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature