RcLS2F - A Novel Fungal Class 1 KDAC Co-repressor Complex in <i>Aspergillus nidulans</i>.

ABSTRACT: The fungal class 1 lysine deacetylase (KDAC) RpdA is a promising target for prevention and treatment of invasive fungal infection. RpdA is essential for survival of the most common air-borne mold pathogen Aspergillus fumigatus and the model organism Aspergillus nidulans. In A. nidulans, RpdA depletion induced production of previously unknown small bioactive substances. As known from yeasts and mammals, class 1 KDACs act as components of multimeric protein complexes, which previously was indicated also for A. nidulans. Composition of these complexes, however, remained obscure. In this study, we used tandem affinity purification to characterize different RpdA complexes and their composition in A. nidulans. In addition to known class 1 KDAC interactors, we i

SUBMITTER: Bauer I 

PROVIDER: S-EPMC7010864 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature