Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response.

ABSTRACT:

Background

There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatment and persisting metabolic activity after apparent clinical cure. This poses a challenge in quantifying scan-based markers of burden of disease and disease activity. We used semi-automated, whole lung quantification of lung lesions to analyse serial FDG PET-CT scans from the Catalysis TB Treatment Response Cohort to identify characteristics that best correlated with clinical and microbiological outcomes.

Results

Quantified scan metrics were already associated with clinical outcomes at diagnosis and 1 month after treatment, with further improved accuracy to differentia

SUBMITTER: Malherbe ST 

PROVIDER: S-EPMC7010890 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature