PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments.

ABSTRACT:

Objective

The liver is regularly exposed to changing metabolic and inflammatory environments. It must sense and adapt to metabolic need while balancing resources required to protect itself from insult. Peroxisome proliferator activated receptor gamma coactivator-1 alpha (PGC-1α) is a transcriptional coactivator expressed as multiple, alternatively spliced variants transcribed from different promoters that coordinate metabolic adaptation and protect against inflammation. It is not known how PGC-1α integrates extracellular signals to balance metabolic and anti-inflammatory outcomes.

Methods

Primary mouse hepatocytes were used to evaluate the role(s) of different PGC-1α proteins in regulating hepatic metabolism and inflammatory signaling downstream of tumor necrosis factor alph

SUBMITTER: Leveille M 

PROVIDER: S-EPMC7011010 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature