Myricetin, the Main Flavonoid in <i>Syzygium cumini</i> Leaf, Is a Novel Inhibitor of Platelet Thiol Isomerases PDI and ERp5.

ABSTRACT:

Background

Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid. Little is known about the potential antiplatelet properties of S. cumini and its constituent flavonoids.

Objective

To evaluate the antiplatelet effects and mechanism of action of a polyphenol-rich extract (PESc) from S. cumini leaf and its most prevalent polyphenols, myricetin and gallic acid.

Methods

PESc, myricetin, and gallic acid were incubated with platelet-rich plasma and washed platelets to assess platelet aggregation and activation. In vitro platelet adhesion and thrombus formation as well a

SUBMITTER: Gaspar RS 

PROVIDER: S-EPMC7011086 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature