Lactate kinetics in ICU patients using a bolus of ¹³C-labeled lactate.

ABSTRACT:

Background

Plasma lactate concentrations and their trends over time are used for clinical prognosis, and to guide treatment, in critically ill patients. Although heavily relied upon for clinical decision-making, lactate kinetics of these patients is sparsely studied.

Aim

To establish and validate a feasible method to study lactate kinetics in critically ill patients.

Methods

Healthy volunteers (n = 6) received a bolus dose of ¹³C-labeled lactate (20 μmol/kg body weight), and 43 blood samples were drawn over 2 h to determine the decay in labeled lactate. Data was analyzed using non-compartmental modeling calculating rates of appearance (R_a) and clearance of lactate. The area under the curve (AUC) was calculated using a linear-up log-down trapezoid

SUBMITTER: Grip J 

PROVIDER: S-EPMC7011254 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature