Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses.

ABSTRACT:

Objective

Numerous genetic variants from meta-analyses of observational studies and GWAS were reported to be associated with migraine susceptibility. However, due to the random errors in meta-analyses, the noteworthiness of the results showing statistically significant remains doubtful. Thus, we performed this field synopsis and re-analysis study to evaluate the noteworthiness using a Bayesian approach in hope of finding true associations.

Methods

Relevant meta-analyses from observational studies and GWAS examining correlation between all genetic variants and migraine risk were included in our study by a PubMed search. Identification of noteworthy associations were analyzed by false-positive rate probability (FPRP) and Bayesian false discovery probability (BFDP). Using notew

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC7011260 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature