C-reactive protein derived from perivascular adipose tissue accelerates injury-induced neointimal hyperplasia.

ABSTRACT:

Aim

Inflammation within the perivascular adipose tissue (PVAT) in obesity plays an important role in cardiovascular disorders. C-reactive protein (CRP) level in obesity patients is significantly increased and associated with the occurrence and progression of cardiovascular disease. We tested the hypothesis CRP derived from PVAT in obesity contributes to vascular remodeling after injury.

Methods

A high-fat diet (HFD) significantly increased CRP expression in PVAT. We transplanted thoracic aortic PVAT from wild-type (WT) or transgenic CRP-expressing (CRPTG) mice to the injured femoral artery in WT mice.

Results

At 4 weeks after femoral artery injury, the neointimal/media ratio was increased significantly in WT mice that received PVAT from CRPTG mice compared with that i

SUBMITTER: Chen JY 

PROVIDER: S-EPMC7011279 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature