Urokinase Plasminogen Activator Overexpression Reverses Established Lung Fibrosis.

ABSTRACT:

Introduction

 Impaired plasminogen activation (PA) is causally related to the development of lung fibrosis. Prior studies demonstrate that enhanced PA in the lung limits the severity of scarring following injury and in vitro studies indicate that PA promotes matrix degradation and fibroblast apoptosis. These findings led us to hypothesize that increased PA in an in vivo model would enhance the resolution of established lung fibrosis in conjunction with increased myofibroblast apoptosis.

Methods

 Transgenic C57BL/6 mice with doxycycline inducible lung-specific urokinase plasminogen activator (uPA) expression or littermate controls were treated (day 0) with bleomycin or saline. Doxycycline was initiated on days 1, 9, 14, or 21. Lung fibrosis, stiffness, apoptosis, epithelial b

SUBMITTER: Horowitz JC 

PROVIDER: S-EPMC7011401 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature