Wolbachia strain wAlbB blocks replication of flaviviruses and alphaviruses in mosquito cell culture.

ABSTRACT: BACKGROUND:Wolbachia pipientis are bacterial endosymbionts of arthropods currently being implemented as biocontrol agents to reduce the global burden of arboviral diseases. Some strains of Wolbachia, when introduced into Aedes aegypti mosquitoes, reduce or block the replication of RNA viruses pathogenic to humans. The wAlbB strain of Wolbachia was originally isolated from Aedes albopictus, and when transinfected into Ae. aegypti, persists in mosquitoes under high temperature conditions longer than other strains. The utility of wAlbB to block a broad spectrum of RNA viruses has received limited attention. Here we test the ability of wAlbB to reduce or block the replication of a range of Flavivirus and Alphavirus species in cell culture. METHODS:The C6/36 mosquito cell line was stably infect

SUBMITTER: Ekwudu O 

PROVIDER: S-EPMC7011541 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature