Genomic measures of inbreeding coefficients and genome-wide scan for runs of homozygosity islands in Iranian river buffalo, Bubalus bubalis.

ABSTRACT:

Background

Consecutive homozygous fragments of a genome inherited by offspring from a common ancestor are known as runs of homozygosity (ROH). ROH can be used to calculate genomic inbreeding and to identify genomic regions that are potentially under historical selection pressure. The dataset of our study consisted of 254 Azeri (AZ) and 115 Khuzestani (KHZ) river buffalo genotyped for ~ 65,000 SNPs for the following two purposes: 1) to estimate and compare inbreeding calculated using ROH (F_ROH), excess of homozygosity (F_HOM), correlation between uniting gametes (F_UNI), and diagonal elements of the genomic relationship matrix (F_GRM); 2) to identify frequently occurring ROH (i.e. ROH islands) for our selection signature and gene enrichment s

SUBMITTER: Ghoreishifar SM 

PROVIDER: S-EPMC7011551 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature