Cathelicidin preserves intestinal barrier function in polymicrobial sepsis.

ABSTRACT:

Objectives

The intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammation. Previous studies reported that cathelicidin is differentially expressed in various tissues in sepsis. However, its role in sepsis-induced intestinal barrier dysfunction has not been investigated.

Design

To examine the role of cathelicidin in polymicrobial sepsis, cathelicidin wild-(Cnlp^+/+) and knockout (Cnlp^-/-) mice underwent cecal-ligation and puncture (CLP) followed by the assessment of septic mortality and morbidity as well as histological, biochemical, immunological, and transcriptomic analyses in the ileal tissues. We also ev

SUBMITTER: Ho J 

PROVIDER: S-EPMC7011568 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature