Quantification of Motor Function in Huntington Disease Patients Using Wearable Sensor Devices.

ABSTRACT: Previous studies have demonstrated the feasibility and promise of wearable sensors as objective measures of motor impairment in Parkinson disease and essential tremor. However, there are few published studies that have examined such an application in Huntington disease (HD). This report provides an evaluation of the potential to objectively quantify chorea in HD patients using wearable sensor data. Data were derived from a substudy of the phase 2 Open-PRIDE-HD study, where 17 patients were screened and 15 patients enrolled in the substudy and ultimately 10 patients provided sufficient wearable sensor data. The substudy was designed to provide high-resolution data to inform design of predictive algorithms for chorea quantification. During the entire course of the 6-month study, in addition

SUBMITTER: Gordon MF 

PROVIDER: S-EPMC7011722 | biostudies-literature | 2019 Sep-Dec

REPOSITORIES: biostudies-literature