Early nasopharyngeal microbial signature associated with severe influenza in children: a retrospective pilot study.

ABSTRACT: A few studies have highlighted the importance of the respiratory microbiome in modulating the frequency and outcome of viral respiratory infections. However, there are insufficient data on the use of microbial signatures as prognostic biomarkers to predict respiratory disease outcomes. In this study, we aimed to evaluate whether specific bacterial community compositions in the nasopharynx of children at the time of hospitalization are associated with different influenza clinical outcomes. We utilized retrospective nasopharyngeal (NP) samples (n=36) collected at the time of hospital arrival from children who were infected with influenza virus and had been symptomatic for less than 2 days. Based on their clinical course, children were classified into two groups: patients with mild influenza,

SUBMITTER: Langevin S 

PROVIDER: S-EPMC7011740 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature