Ionic Hydrogel for Accelerated Dopamine Delivery via Retrodialysis.

ABSTRACT: Local drug delivery directly to the source of a given pathology using retrodialysis is a promising approach to treating otherwise untreatable diseases. As the primary material component in retrodialysis, the semipermeable membrane represents a critical point for innovation. This work presents a new ionic hydrogel based on polyethylene glycol and acrylate with dopamine counterions. The ionic hydrogel membrane is shown to be a promising material for controlled diffusive delivery of dopamine. The ionic nature of the membrane accelerates uptake of cationic species compared to a nonionic membrane of otherwise similar composition. It is demonstrated that the increased uptake of cations can be exploited to confer an accelerated transport of cationic species between reservoirs as is desired in ret

SUBMITTER: Proctor CM 

PROVIDER: S-EPMC7011752 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature