Early molecular oxidative stress biomarkers of ischemic penumbra in acute stroke.

ABSTRACT:

Objectives

To assess whether plasma biomarkers of oxidative stress predict diffusion-perfusion mismatch in patients with acute ischemic stroke (AIS).

Methods

We measured plasma levels of oxidative stress biomarkers such as F2-isoprostanes (F2-isoPs), total and perchloric acid Oxygen Radical Absorbance Capacity (ORAC_TOT and ORAC_PCA), urinary levels of 8-oxo-7,8-dihydro-2'-deoxyguoanosine, and inflammatory and tissue-damage biomarkers (high-sensitivity C-reactive protein, matrix metalloproteinase-2 and -9) in a prospective study of patients with AIS presenting within 9 hours of symptom onset. Diffusion-weighted (DWI) and perfusion-weighted (PWI) MRI sequences were analyzed with a semiautomated volumetric method. Mismatch was defined as baseline mean trans

SUBMITTER: Lorenzano S 

PROVIDER: S-EPMC7011868 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature