Single nucleotide mapping of trait space reveals Pareto fronts that constrain adaptation.

ABSTRACT: Trade-offs constrain the improvement of performance of multiple traits simultaneously. Such trade-offs define Pareto fronts, which represent a set of optimal individuals that cannot be improved in any one trait without reducing performance in another. Surprisingly, experimental evolution often yields genotypes with improved performance in all measured traits, perhaps indicating an absence of trade-offs at least in the short term. Here we densely sample adaptive mutations in Saccharomyces cerevisiae to ask whether first-step adaptive mutations result in trade-offs during the growth cycle. We isolated thousands of adaptive clones evolved under carefully chosen conditions and quantified their performances in each part of the growth cycle. We too find that some first-step adaptive mutations ca

SUBMITTER: Li Y 

PROVIDER: S-EPMC7011918 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature