Acute insertion effects of penetrating cortical microelectrodes imaged with quantitative optical coherence angiography.

ABSTRACT: The vascular response during cortical microelectrode insertion was measured with amplitude decorrelation-based quantitative optical coherence angiography (OCA). Four different shank-style microelectrode configurations were inserted in murine motor cortex beneath a surgically implanted window in discrete steps while OCA images were collected and processed for angiography and flowmetry. Quantitative measurements included tissue displacement (measured by optical flow), perfused capillary density, and capillary flow velocity. The primary effect of insertion was mechanical perturbation, the effects of which included tissue displacement, arteriolar rupture, and compression of a branch of the anterior cerebral artery causing a global decrease in flow. Other effects observed included local flow dr

SUBMITTER: Hammer DX 

PROVIDER: S-EPMC7011942 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature