DNA Repair Biomarker for Lung Cancer Risk and its Correlation With Airway Cells Gene Expression.

ABSTRACT:

Background

Improving lung cancer risk assessment is required because current early-detection screening criteria miss most cases. We therefore examined the utility for lung cancer risk assessment of a DNA Repair score obtained from OGG1, MPG, and APE1 blood tests. In addition, we examined the relationship between the level of DNA repair and global gene expression.

Methods

We conducted a blinded case-control study with 150 non-small cell lung cancer case patients and 143 control individuals. DNA Repair activity was measured in peripheral blood mononuclear cells, and the transcriptome of nasal and bronchial cells was determined by RNA sequencing. A combined DNA Repair score was formed using logistic regression, and its correlation with disease was assessed using cross-validatio

SUBMITTER: Paz-Elizur T 

PROVIDER: S-EPMC7012022 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature