Gamma-linolenic acid ameliorated glycation-induced memory impairment in rats.

ABSTRACT:

Context

γ-Linolenic acid (GLA) is an important constituent of anti-ageing supplements.

Objective

The current study investigates the anti-ageing effect of GLA in Sprague-Dawley rats.

Materials and methods

GLA (0.1, 0.2, 0.4, 2, 10, 20 and 24 μM) was initially evaluated for its effect on the formation of advanced glycation end products (AGEs) in vitro. For in vivo assessment (1, 5 or 15 mg/kg), the rat model of accelerated ageing was developed using d-fructose (1000 mg/kg (i.p.) plus 10% in drinking water for 40 days). Morris water maze was used to evaluate impairment in learning and memory. The blood of treated animals was used to measure glycosylated haemoglobin (HbA1c) levels. The interaction of GLA with active residues of receptor of AGE (RAGE) was analyzed using Au

SUBMITTER: Khan SA 

PROVIDER: S-EPMC7012036 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature