CXCR4-targeted PET imaging using ⁶⁴Cu-AMD3100 for detection of Waldenstrom Macroglobulinemia.

ABSTRACT: Objective:  Waldenström Macroglobulinemia (WM) is a rare B-cell malignancy characterized by secretion of immunoglobulin M and cancer infiltration in the bone marrow. Chemokine receptor such as CXCR4 and hypoxic condition in the bone marrow play crucial roles in cancer cell trafficking, homing, adhesion, proliferation, survival, and drug resistance. Herein, we aimed to use CXCR4 as a potential biomarker to detect hypoxic-metastatic WM cells in the bone marrow and in the circulation by using CXCR4-detecting radiopharmaceutical.Methods: We radiolabeled a CXCR4-inhibitor (AMD3100) with ⁶⁴Cu and tested its binding to WM cells with different levels of CXCR4 expression using gamma counter in vitro. The accumulation of this radiopharmaceutical tracer was tested i

SUBMITTER: Muz B 

PROVIDER: S-EPMC7012167 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature