Mitochondrial DNA Haplogroups and Delirium During Sepsis.

ABSTRACT:

Objectives

Studies suggest that mitochondrial dysfunction underlies some forms of sepsis-induced organ failure. We sought to test the hypothesis that variations in mitochondrial DNA haplogroup affect susceptibility to sepsis-associated delirium, a common manifestation of acute brain dysfunction during sepsis.

Design

Retrospective cohort study.

Setting

Medical and surgical ICUs at a large tertiary care center.

Patients

Caucasian and African American adults with sepsis.

Measurements and main results

We determined each patient's mitochondrial DNA haplogroup using single-nucleotide polymorphisms genotyping data in a DNA databank and extracted outcomes from linked electronic medical records. We then used zero-inflated negative binomial regression to analyze a

SUBMITTER: Samuels DC 

PROVIDER: S-EPMC7012366 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature