Alzheimer's disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation.

ABSTRACT: The clinical spectrum of Alzheimer's disease (AD) extends well beyond the classic amnestic-predominant syndrome. The previous studies have suggested differential neurofibrillary tangle (NFT) burden between amnestic and logopenic primary progressive aphasia presentations of AD. In this study, we explored the regional distribution of NFT pathology and its relationship to AD presentation across five different clinical syndromes. We assessed NFT density throughout six selected neocortical and hippocampal regions using thioflavin-S fluorescent microscopy in a well-characterized clinicopathological cohort of pure AD cases enriched for atypical clinical presentations. Subjects underwent apolipoprotein E genotyping and neuropsychological testing. Main cognitive domains (executive, visuospatial, la

SUBMITTER: Petersen C 

PROVIDER: S-EPMC7012374 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature