Genome analysis of myelodysplastic syndromes among atomic bomb survivors in Nagasaki.

ABSTRACT: Ionizing radiation is a risk factor for myeloid neoplasms including myelodysplastic syndromes (MDS), and atomic bomb survivors have been shown to have a significantly higher risk of MDS. Our previous analyses demonstrated that MDS among these survivors had a significantly higher frequency of complex karyotypes and structural alterations of chromosomes 3, 8, and 11. However, there was no difference in the median survival time between MDS among survivors compared with those of de novo origin. This suggested that a different pathophysiology may underlie the causative genetic aberrations for those among survivors. In this study, we performed genome analyses of MDS among survivors and found that proximally exposed patients had significantly fewer mutations in genes such as TET2 al

SUBMITTER: Taguchi M 

PROVIDER: S-EPMC7012461 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature