Ontology highlight
ABSTRACT:
SUBMITTER: Greenwood DJ
PROVIDER: S-EPMC7012645 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20190627 6447
Tuberculosis, caused by the intracellular pathogen <i>Mycobacterium tuberculosis</i>, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means that it is unclear whether antibiotics penetrate all mycobacteria-containing compartments in the cell. Here, we combined correlated light, electron, and ion microscopy to image the distribution ...[more]