Alveolar Bone Protection by Targeting the SH3BP2-SYK Axis in Osteoclasts.

ABSTRACT: Periodontitis is a bacterially induced chronic inflammatory condition of the oral cavity where tooth-supporting tissues including alveolar bone are destructed. Previously, we have shown that the adaptor protein SH3-domain binding protein 2 (SH3BP2) plays a critical role in inflammatory response and osteoclastogenesis of myeloid lineage cells through spleen tyrosine kinase (SYK). In this study, we show that SH3BP2 is a novel regulator for alveolar bone resorption in periodontitis. Micro-CT analysis of SH3BP2-deficient (Sh3bp2 ^-/- ) mice challenged with ligature-induced periodontitis revealed that Sh3bp2 ^-/- mice develop decreased alveolar bone loss (male 14.9% ± 10.2%; female 19.0% ± 6.0%) compared with wild-type control mice (male 25.3% ± 5.8%; female 30.8% ± 5.8%). L

SUBMITTER: Kittaka M 

PROVIDER: S-EPMC7012678 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature