Kidney Biomarkers of Injury and Repair as Predictors of Contrast-Associated AKI: A Substudy of the PRESERVE Trial.

ABSTRACT:

Rationale & objective

The PRESERVE trial used a 2 × 2 factorial design to compare intravenous saline solution with intravenous sodium bicarbonate solution and oral N-acetylcysteine with placebo for the prevention of 90-day major adverse kidney events and death (MAKE-D) and contrast-associated acute kidney injury (CA-AKI) among patients with chronic kidney disease undergoing angiography. In this ancillary study, we evaluated the predictive capacities of preangiography injury and repair proteins in urine and plasma for MAKE-D, CA-AKI, and their impact on trial design.

Study design

Longitudinal analysis.

Setting & participants

A subset of participants from the PRESERVE trial.

Exposures

Injury (KIM-1, NGAL, and IL-18) and repair (MCP-1, UMOD, and YKL-40) proteins i

SUBMITTER: Parikh CR 

PROVIDER: S-EPMC7012712 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature